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Health Information

Bupropion (Zyban®)

Bupropion (Zyban®)

If you want to stop smoking, taking bupropion (trade name Zyban®) roughly doubles your chance of success.

If you want to stop smoking, taking bupropion (trade name Zyban®) roughly doubles your chance of success.

Most people who quit smoking have tried three or four times to do so before they succeed. This is because smoking, or more specifically nicotine in cigarette smoke, is highly addictive. You start to get withdrawal symptoms only a few hours after smoking a cigarette. Bupropion (Zyban®) can help by reducing these withdrawal symptoms.

You can read more about how addictive smoking can be and also find out how addicted you are.

Bupropion (Zyban®) is a medicine that was first developed to treat depression. It was found that it helped smokers to stop smoking. It is not clear how it works. It alters the level of some chemicals in the brain (neurotransmitters). This seems to relieve the withdrawal symptoms that you experience when you stop smoking (such as craving, feeling anxious, restlessness, headaches, irritability, hunger, difficulty concentrating, or just feeling awful).

Taking bupropion does increase the chance of quitting smoking. Various studies have looked at this issue. The studies compared bupropion to a similar dummy (placebo) tablet in people who were keen to stop smoking. The results from the studies showed that, on average, about 19 in 100 people who took bupropion stopped smoking successfully. This compared to about 10 in 100 who took the dummy tablet. In other words, about twice the number of smokers who take bupropion stop smoking compared to those who don't take bupropion. About 1 in 5 smokers who want to stop will do it with the help of bupropion.

  • You need a prescription to obtain bupropion - you cannot buy it at pharmacies.
  • Start by taking one tablet (150 mg) each day for six days. Then increase to one tablet twice a day, at least eight hours apart. Do not take more than one tablet at any one time, and not more than two tablets in a day. (If you are elderly or if you have certain liver or kidney diseases, the dose may be different - your doctor will advise.)
  • Set a target date to stop smoking one to two weeks after starting treatment. This allows bupropion to build up in your body before you stop completely.
  • You should continue the tablets for a further seven weeks. (So, this is eight weeks in total, which is two packs of tablets.)

Bupropion does not 'make' you stop smoking. You still need determination to succeed and to break the smoking habit. A combination of bupropion with counselling from a nurse, doctor, pharmacist or other health professional increases your chance of successfully stopping smoking. Therefore, most doctors will only prescribe bupropion to people who really want to stop smoking as part of a 'stopping smoking' programme.

Most people take bupropion without any problem. Read the packet leaflet for a full list of possible side-effects and cautions. The most common are a dry mouth (which occurs in about 1 in 10 users) and some difficulty in sleeping (which occurs in about 1 in 3 users). Less common but more serious possible side-effects include the following:


If this occurs you should not drive or operate machinery.

A seizure (fit or convulsion)

This occurs in about 1 in 1,000 people who take bupropion. Therefore, although this is uncommon, it can be serious, particularly if it occurs when you are operating machinery or driving. The risk of a seizure is increased if you have a history of certain medical conditions, or if you take certain medicines (listed below). Therefore, bupropion is not suitable for all people who wish to stop smoking (see below).

High blood pressure

Blood pressure sometimes goes up in people who take bupropion. You should have a baseline blood pressure reading done before you start treatment and it should be monitored from time to time.

If you think you have had a side-effect to bupropion, you can report this in the UK on the Yellow Card Scheme. This is a scheme that alerts health professionals to unexpected side-effects, especially to new medicines. You can do it online here:

You should not take bupropion if you:

  • Are under the age of 18 years.
  • Are pregnant or breast-feeding.
  • Have ever had epilepsy, a seizure (fit or convulsion), or an unexplained blackout.
  • Have ever had anorexia nervosa or bulimia nervosa.
  • Have bipolar affective disorder (manic depression).
  • Are withdrawing abruptly from benzodiazepines or alcohol dependence.
  • Have a tumour of the brain or spinal cord.
  • Have had a previous allergic reaction to bupropion tablets.

Also, the dose may need to be reduced if you have some medical conditions or if you take certain medicines. Tell your doctor or pharmacist if you:

  • Have ever had a serious head injury.
  • Have diabetes that is treated with insulin or medicines.
  • Drink a lot of alcohol.
  • Have a liver or kidney disease.

Bupropion combined with certain other medicines can increase the risk of having a seizure. Therefore, whilst you are taking bupropion, tell your doctor or pharmacist if you are prescribed or buy any new medicine. Also, tell a doctor or pharmacist if you are taking any of the following medicines:

  • Antimalarial medicines (for example, chloroquine, proguanil).
  • Antihistamines.
  • Medicines to treat depression or other mental illness.
  • Theophylline, which is a medicine used to treat chest conditions.
  • Steroids - taken as tablets or injections.
  • Antibiotics.
  • Tramadol, which is a strong painkiller.
  • Slimming medicines or other stimulant medicines.

If you are unable to take bupropion, there are other ways that you can get help to quit. Read more about how to stop smoking.

Further reading & references

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Patient Platform Limited has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Consult a doctor or other healthcare professional for diagnosis and treatment of medical conditions. For details see our conditions.

Dr Jacqueline Payne
Peer Reviewer:
Dr Adrian Bonsall
Document ID:
4544 (v42)
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